In our powerfuse environment we came across this problem recently.
When we would try to launch an App-V application the following window would open and remain open for 30 + seconds before finally opening the application:
The problem we discovered was to do with file type associations inside of the RES session, App-V by default will try to associate it’s file type associations for the application being sequenced and store them in the .osd file. The problem was that PowerFuse also controls file associations and this became an issue! PowerFuse has to be associated with the app and not vice versa.
I recommend you specify the file type associations inside of powerfuse and remove the associations inside of the App-V package. To remove the associations, open the .osd file and remove anything between the <FILEEXTENSIONLIST> </FILEEXTENSION>:
After the link is an example.